Articles Tagged With:
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Zuranolone Trial Shows Early Promise as an Oral Neuroactive Steroid for the Treatment of Postpartum Depression
Zuranolone was approved by the Food and Drug Administration for the treatment of postpartum depression (PPD) in March 2019. One potential factor identified in PPD etiology is the dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid with gamma-aminobutyric acid type A (GABAA) receptor positive allosteric modulator properties. In brain regions associated with emotion and self-perception, neural network connectivity supported by GABAergic signaling is positively correlated with plasma allopregnanolone concentrations in individuals with PPD vs. healthy postpartum female individuals.
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Is Prenatal Screening for GBS Cost-Effective in the United States?
In this cost-effectiveness study, screening for group B streptococcus (GBS) at 36 0/7 to 37 6/7 weeks, with rescreening (if GBS results are negative after five weeks of initial screening), is the most cost-effective strategy.
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Barriers to Abortion Care and Self-Managed Abortion
In this prospective national study among people searching for abortion care online, 28% of respondents reported attempting self-managed abortion. Respondents living farther from an abortion facility and facing barriers to care were more likely to attempt self-managed abortion.
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Left-Sided Breast Cancer Radiation Therapy and Coronary Artery Disease
A study of breast cancer survivors revealed left breast radiation therapy doubles the subsequent risk of coronary heart disease vs. right-sided radiation.
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Long-Term Post-TAVR Survival and Permanent Pacemaker Implantation
An analysis of a real-world database revealed 14% of patients undergoing routine transfemoral transcatheter aortic valve replacement required permanent pacemaker implantation within 30 days of the valve procedure. There was no difference in long-term survival between patients who did and did not undergo pacemaker implant.
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Importance of Age in the Application of Coronary Artery Calcium Detection
Using coronary CT strategy as a diagnostic first line in patients with symptoms suggestive of coronary artery obstruction revealed relying on the coronary calcium score alone is inadequate for younger patients with a higher frequency of non-calcified obstructions.
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Coronary CT Angiography in the General Population
Coronary artery CT angiography in asymptomatic, middle-aged subjects without known coronary artery disease showed coronary atherosclerosis is common but mostly mild and appears in women after a 10-year delay.
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Intensive Monitoring for Asymptomatic Atrial Fibrillation Did Not Prevent Strokes
Screening with an implantable loop recorder resulted in dramatically higher rates of atrial fibrillation detection and ensuing anticoagulation, but without a significant decrease in risk of stroke or systemic embolism by six years of follow-up.
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Evaluation and Management of Hypertension in Adults
Hypertension, defined by most major societies as > 140/90 mmHg, is common and the prevalence is increasing.
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College Students Need Better STI, Sexual Violence Education
Nearly two-thirds of college students reported having experienced sexual and/or physical violence at some time in their lives, according to the results of a new study.